5-(R,S)-t-trans-cinnamido-7-methyl-4-oxo-octanoyl-L-Protyl-L-Proline.
F.W. 512
Prepared by the method of Grobelny and Galardy (26).
Purity is 95% as determined by thin layer chromatography and NMR.
Inhibits Clostridium histolyticum collagenases.
Ki = 1 µM for B-collagenase, 18 nM for E-collagenase, complete inhibition at 20 µM.
The inhibitor is hygroscopic and should be stored over desiccant.
Molecular Weight = 511.62
Exact Mass = 511
Molecular Formula = C28H37N3O6
Molecular Composition = C 65.73% H 7.29% N 8.21% O 18.76%